[Demelerlab] Report on the F19CHa Amyloid Beta Characterization by AUC

[James S. Nowick]

Hi Borries,

Thanks for the report. Jason and I look forward to discussing it with each other and then setting up a meeting with you to follow up.

Given the appearance of the graphs in Figure 3, I am confused about the following sentence: "Nevertheless, we
can detect sedimentation signal in the region of 0.1-1.5 s, consistent with the presence of monomer-dodecamer,
with a prevalence of the monomer in all cases.” Looking at the graphs, I see no evidence of dodecamer. Am I missing something?

Thanks,
James

> On Sep 18, 2023, at 4:00 PM, Borries Demeler <demeler at gmail.com> wrote:
> 
> Dear James and Jason,
> 
> Aysha in my lab prepared the attached and detailed report on the F19CHa amyloid beta characterization by AUC.
> I went over the results with her and this is the summary of these results.
> 
> Please review the report and we can schedule a meeting to discuss the results further if you have any questions.
> 
> Regards, -Borries
> <AmyloidBeta-report-091723.pdf>

James S. Nowick
Distinguished Professor
Department of Chemistry & Department of Pharmaceutical Sciences

Department of Chemistry
4126 Natural Sciences 1
University of California, Irvine
Irvine, CA 92697-2025

Phone:  (949)  824-6091
e-mail: jsnowick at uci.edu
Faculty Web Page: http://tinyurl.com/jsnowick/
Research Group Web Page: http://tinyurl.com/nowickgroup/
Pronouns: he/him/his

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