[Demelerlab] NIST standards

[Borries Demeler]

Hello Jeff,
Thank you very much for your positive feedback, and interest in a
collaboration to help us move this forward!

I sent out an invite for Thursday, Feb. 1st at 12:00 pm MST/2:00 pm EST,
feel free to invite others from your team. I am including members from our
team involved with this project, in particular Reece, a grad student who
you may remember from AUC2022, who is in charge of this project. I propose
we give Reece ~ 10 minutes at the beginning of the meeting to update all of
us on the progress he has made, and to show the preliminary data he has
collected. Thank you also for noting the two items of concern, which I also
would like to discuss further. I am excited that you are interested in this
project, and look forward to a fruitful collaboration!

See you next Thursday on Zoom.

Best wishes, -Borries

On Thu, Jan 25, 2024 at 6:10 AM Fagan, Jeffrey A. Dr. (Fed) <
jeffrey.fagan at nist.gov> wrote:

> Dear Bo,
>
>
>
> Thank you for reaching back out. My apologies for not getting back to you
> on this over the summer too.  I’ve just been overwhelmed.
>
> I did send out feelers across NIST to our DNA and genomic standards folks,
> but I do not believe I ever heard a specific answer.  I will follow up on
> this.
>
> One of the questions I have, having read the paper when it was published
> so it’s not fresh in my mind, is whether you are thinking about an actual
> product being sold, or a documentary standard that says “buy these DNAs,
> run them this way, this should be your result.”
>
> My memory is that the shelf life and easy obtainability of (exactly)
> identical materials seemed to be potential issues for either scenario.
>
>
>
> It is also likely in either case that if the material is intended solely
> for AUC that the person may be me, or Chris Sims, who is my project team
> member currently doing most of our AUC experiments.  Chris will be at the
> meeting in Philly next month and hopefully at the AUC meeting (the budget
> is tough this FY and my chance of attending seems very close to 0).
>
>
>
> For some context, NIST has become very stingy about issuing new actual
> reference materials in recent years, but commercially reproducible
> materials can also serve as a basis for documentary standards.  Regardless,
> a likely activity would include conducting a two+ round interlaboratory
> comparison demonstrating that first a single source of the material yields
> reproducible results across labs, and then that independently acquired (or
> additional production batches depending) also yield consistent results
> (within some uncertainty, which is essentially being codetermined).  There
> is a goodly amount of effort that goes into both paths.
>
>
>
> As a path forward, I suggest we have a zoom meeting next week.  Monday
> from 1-4 EST, Wednesday 1-2:30 EST or Thurs 2-4 EST are all open windows if
> one of those works on your end.
>
>
>
> Best,
>
> Jeff
>
>
>
>
>
> *From:* Borries Demeler <demeler at gmail.com>
> *Sent:* Wednesday, January 24, 2024 6:39 PM
> *To:* Fagan, Jeffrey A. Dr. (Fed) <jeffrey.fagan at nist.gov>
> *Subject:* NIST standards
>
>
>
> Hello Jeff,
>
> I hope this email finds you well!
>
> I wanted to pick up on our conversation during AUC 2022 about the
> molecular standards. We are looking for a collaborator at NIST who would be
> able to help us provide some guidance on the development of a molecular
> standard for AUC. We have what I believe to be a pretty good plan, and I
> was wondering if you would be interested in this. If so, I propose we have
> a zoom call with the student developing this project and go from there?
>
> best wishes, -Borries
>
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